Antimicrobial screening of stembark extracts of Vitellaria paradoxa against some enteric pathogenic microorganisms
El-Mahmood, Doughari, Ladan
African Journal of Pharmacy and Pharmacology
Abstract
Preliminary phytochemical screening of the stem bark extracts of Vitellaria paradoxa revealed the presence of carbohydrates, alkaloids, saponins, tannins and cardiac glycosides. Ethanol, acetone and aqueous extracts of the plant inhibited the growth of pathogenic Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Shigella dysenterie and Salmonella typhi with varying degrees of activity with the ethanol extracts demonstrating the highest activity against all the test organisms. The activity of the extracts increased as the pH was adjusted towards alkalinity, but no significant increase was observed with increase in temperature. The MBC and MIC values ranged between 6.5 - 200 mg/ml and to some extent comparable to those of the conventional antibiotic chloramphenicol (6.5 mg/ml). There is scientific basis for the use of this plant as a traditional medicine and can therefore be used to source new antibiotic substances for the treatment of various enteric infections. Key words: Antibiotic, enteric infections, extracts, MBC, MIC, pathogenic, phytochemical screening, Vitellaria paradoxa.
Extracted Claims
5 claims extracted from this paper into the knowledge graph
stem bark extracts of Vitellaria paradoxa inhibited growth of pathogenic Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Shigella dysenterie and Salmonella typhi
“Ethanol, acetone and aqueous extracts of the plant inhibited the growth of pathogenic Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Shigella dysenterie and Salmonella typhi with varying d...”
MBC and MIC values of stem bark extracts of Vitellaria paradoxa ranged between 6.5 - 200 mg/ml
“The MBC and MIC values ranged between 6.5 - 200 mg/ml and to some extent comparable to those of the conventional antibiotic chloramphenicol (6.5 mg/ml).”
ethanol extracts of Vitellaria paradoxa demonstrated highest activity against all the test organisms
“Ethanol, acetone and aqueous extracts of the plant inhibited the growth of pathogenic Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Shigella dysenterie and Salmonella typhi with varying d...”