ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson’s disease
Hongxia Cai, Xing Cheng, Xiaoping Wang
Hepatology
Abstract
We established a system of autologous reprogrammed WD hepatocytes and achieved ATP7B gene therapy in vitro. LPC-ATP7B-Heps transplantation demonstrated therapeutic efficacy on copper homeostasis in a mouse model of WD.
Concepts
TransplantationCancer researchBiologyHepatocyteProgenitor cell