Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation
Changyu Wu, Qing Hu, Xichun Peng, Jianming Luo, Guangwen Zhang
Journal of Agricultural and Food Chemistry
Abstract
The metabolic disease hyperuricemia (HUA) is characterized by a disturbance in purine metabolism. Peptides, such as marine fish-derived peptides, have previously been shown to be effective in alleviating HUA. In this study, HUA rats were induced by potassium oxonate with 100 mg/kg (L), 200 mg/kg (M), and 400 mg/kg (H) of marine fish protein peptide (MFPP). The results showed that MFPP could effectively reduce the serum uric acid (SUA) levels compared with the model group rats; kidney histopathology and the levels of inflammatory factors (TNF-α, IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney inflammation. Meanwhile, MFPP restored the abundance of beneficial bacteria, including <i>Lactobacillus</i>, <i>Blautia</i>, <i>Colidextribacter</i>, and <i>Intestinimonas</i>. MFPP further repaired the intestinal barrier by recovering the expression of gene <i>Ildr2</i> encoding the tricellular tight junction protein ILDR2 and the immune-related genes <i>Ccr7</i> and <i>Nr4a3</i> and also regulated the expression of <i>Entpd8</i> and <i>Cyp27b1</i> to restore kidney function and uric acid metabolism. MFPP was proved to have potential as a therapeutic strategy to be included in dietary intervention to relieve HUA.
Extracted Claims
5 claims extracted from this paper into the knowledge graph
marine fish protein peptide (MFPP) restores abundance of beneficial bacteria
“MFPP restored the abundance of beneficial bacteria, including <i>Lactobacillus</i>, <i>Blautia</i>, <i>Colidextribacter</i>, and <i>Intestinimonas</i>”
marine fish protein peptide (MFPP) regulates expression of genes
“MFPP further repaired the intestinal barrier by recovering the expression of gene <i>Ildr2</i> encoding the tricellular tight junction protein ILDR2 and the immune-related genes <i>Ccr7</i> and <i>Nr4...”
marine fish protein peptide (MFPP) attenuates kidney inflammation
“kidney histopathology and the levels of inflammatory factors (TNF-α, IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney inflammation”